They were together for 12 years, but sadly it was not meant to be.
The love story of Brangelina all began on the set of Mr. and Mrs. Smith in 2004.
Read: Jon Voight On Daughter Angelina Jolie's Divorce From Brad Pitt: 'Say A Little Prayer'
Brad Pitt and Angelina Jolie have said they “fell in love” while playing married assassins.
At the time, Pitt was married to Jennifer Aniston and eventually left the Friends star for Jolie in 2005, months before the film was released.
Aniston’s fans are reacting to the announcement that Brangelina are splitting up by posting messages online.
I'm not torn up over #Brangelina's split. Sorry, totally team #JenniferAniston. Always have been. pic.twitter.com/m1cezyD1w2
— Teresa Sabga (@teresamarias) September 20, 2016
Gimme a K
— Uplike (@Uplike) September 20, 2016
Gimme an A
Gimme an R
Gimme an M
Gimme an A
Gimme KARMA #BRANGELINA #JenniferAniston Jennifer Aniston?https://t.co/RRzHoT1Es6 pic.twitter.com/0rlPUpRM0a
The #JenniferAniston memes are almost worth the broken family. #brangelina pic.twitter.com/azBqdSEenK
— Lauren Luxford (@LNLux) September 20, 2016
The most disappointing thing about the #brangelina split is #JenniferAniston doesn't have social media to enjoy all the memes about her.
— Miss Klonk (@MissKlonk) September 20, 2016
In 2006, Pitt and Jolie had their first child together — Shiloh. Two years later, they had twins, Knox and Vivienne. The couple also has 3 adopted children together, Zahara, Pax and Maddox.
In 2013, their world was rocked when Jolie announced she had undergone a double mastectomy. Her mother had died of breast cancer and she wasn’t taking any chances.
A year later, at request of their six kids, they surprised the world by getting married in a secret ceremony at their estate in France — Chateau Miraval. Jolie’s dress was decorated with the drawings of their children.
Read: Brangelina Is No More: Angelina Jolie Files for Divorce From Brad Pitt
It was Pitt’s second marriage and Jolie’s third. In 1996 she married her Hackers co-star Johnny Lee Miller, divorcing three years later. In 2000, she married actor Billy Bob Thornton, and they divorced three years later.
In 2015, Jolie directed her husband and herself in the box-office bomb, By The Sea. It marked the second time they worked together.
The film was centered around a couple vacationing in France while trying to save their 14-year marriage.
Watch: Drew Barrymore Puts On a Brave Face After Announcing Her Divorce From Third Husband
