It's the latest salvo in the war of words between the comedian and the president.
First lady Melania Trump is now caught in the middle of the never-ending feud between the president and Rosie O'Donnell.
Read: MIA Melania? First Lady Makes Rare Public Appearance Amid Reports She's Reclusive
After Trump's third wife presented at The International Women of Courage Awards in Washington earlier this week, she tweeted: "I urge you to not be afraid to fail — as failure will never have the power to define you, as long as you learn from it."
Read: Melania Spends the Weekend in Mar-a-Lago Without Trump Following Failed Health Care Bill
The message prompted Rosie O’Donnell to reply, taking an opportunity to blast her old foe in the process.
"Which is y u need to divorce him -- take ur son n parents and FLEE," O'Donnell tweeted.
@FLOTUS - which is y u need to divorce him - take ur son n parents and FLEE
— ROSIE (@Rosie) March 29, 2017
Donald Trump and the comedian have been at each other’s throats for years, with each of them making fiery public comments at each other.
Watch: Yuge Profit: President Trump's Childhood Home Flipped for $750,000 Gain
