The "Pirates of the Caribbean" star's comments follow the now-notorious image of Kathy Griffin holding a mock-up of Trump's severed head.
Johnny Depp has come under fire over a crack he made about assassinating President Trump at the Glastonbury Music and Arts Festival in England.
Read: Johnny Depp in Financial Crisis Due to Extravagant Spending, Lawsuit Says
The trouble started Thursday, the first day of the festival, when the Pirates of the Caribbean star brought up the president.
"Can you bring Trump here?” Depp said as a chorus of boos rained down from the crowd.
As a chorus of boos rained on the actor, he tried to clarify his comments to the hostile audience.
“You misunderstand completely," he said. "When was the last time an actor assassinated a president? I want to clarify. I’m not an actor. I lie for a living. However, it's been awhile, and maybe it's time."
That, of course, was a reference to the assassination of President Lincoln by the actor John Wilkes Booth at Ford's Theatre in 1865.
“By the way, this is going to be in the press and it'll be horrible," he said, apparently realizing the consequences of his remarks. "It's just a question; I’m not insinuating anything."
On Friday afternoon, Depp said he was sorry in a statement to People magazine.
“I apologize for the bad joke I attempted last night in poor taste about President Trump. It did not come out as intended, and I intended no malice. I was only trying to amuse, not to harm anyone," he said.
The Secret Service says it was “aware of the comment.”
Speaking to The Washington Post Friday, Kellyanne Conway called Depp a “nut job.”
And Conway wasn't the only one defending the commander in chief, as Donald Trump Jr. took aim at Depp by reminding his 1.7 million Twitter followers about "alleged abuse of Amber Heard," the actor's ex-wife. Depp denies the allegations.
Ha, Depp wants to make social commentary: Johnny Depp's team knew of alleged abuse of Amber Heard https://t.co/WyybzEx3hT via @MailOnline
— Donald Trump Jr. (@DonaldJTrumpJr) June 23, 2017
Depp's comments come on the heels of outrage over the now-notorious image of Kathy Griffin holding the severed head of Donald Trump and the controversial assassination of a Trump-like character in a New York production of Shakespeare’s Julius Caesar.
Read: Trump Supporter Rushes Stage During Performance of Controversial 'Julius Caesar' Adaptation
Madonna also made an "explosive" remark at the Women's March on Washington shortly after Trump’s Inauguration, when she said it was time to “blow up the White House.”
Watch: Tearful Kathy Griffin Claims Trump Family Is 'Personally Trying to Ruin My Life'