The singer called the couple's divorce: 'The end of an era.'
Performing in New York City Tuesday night, Adele dedicated her entire Madison Square Garden set to Brad Pitt and Angelina Jolie following their shocking split.
Read: Brad Pitt and 'Allied' Co-Star Marion Cotillard Deny Affair Rumors Amid Brangelina Split
According to fans posting on social media, she said: "I need to address the elephant in the room. It's the end of an era!"
The "Send My Love (To Your New Lover)" singer is said to be "so sad" over the divorce.
The fans in attendance tweeted about the dedication to Hollywood’s favorite couple.
Now #Adele is leading us all in a group Brangelina breakup therapy session. Also, there are songs.
— Kristopher Jansma (@KristopherJans) September 21, 2016
Adele just dedicated her NYC show to #Brangelina. "I need to address the elephant in the room ... It's the end of an era!" #AdeleMSG
— Nick Hautman (@nickhautman) September 21, 2016
"Can we talk about the elephant in the room, that #Brangelina broke up?" - Adele at #AdeleMSG tonight. #AdeleLive2016 #RIPBrangelina
— Gibson Johns (@gibsonoma) September 21, 2016
Enjoying me some @Adele @TheGarden. Perfect music to help me cope with a #Brangelina free world. pic.twitter.com/78NCu8EorP
— Silvio Pietroluongo (@silpiet) September 21, 2016
The news of the Pitt and Jolie breakup stunned the entertainment industry when it was announced Tuesday morning. The couple is citing “irreconcilable differences” as the cause to their divorce.
Read: From 'Mr. and Mrs. Smith' to Mr. and Mrs. Split: A Timeline of Brangelina's Relationship
The Grammy-winning British singer is in the middle of a six-night sold-out run at the storied New York arena.
Watch: Adele Rejects Super Bowl Halftime Show, NFL Claims She Was Never Given Formal Offer