Dave Chappelle and other stars have also paid tribute to the late 57-year-old comedian.
Eddie Murphy was among numerous comics and film stars opening up about the loss of his older brother, Charlie, who died Wednesday after a battle with leukemia.
Read: Comedian and Actor Charlie Murphy Dead at 57
"Our hearts are heavy with the loss today of our son, brother, father, uncle and friend Charlie," the Beverly Hills Cop star said in a statement to Variety. "Charlie filled our family with love and laughter and there won't be a day that goes by that his presence will not be missed."
Charlie Murphy, 57, who also worked as a comedian and actor, died in a New York City hospital as he was undergoing chemotherapy for his fight against the disease.
Before taking to the comedy stage, he served in the U.S. Navy for six years.
Charlie, who's a year older than Eddie, had a long and prolific career. His first movie role came in 1989 with Harlem Nights, which was written, produced and directed by Eddie.
Charlie Murphy also co-wrote the screenplays for Vampire in Brooklyn and Norbit, which starred his brother.
As an actor, he was best known for appearing on Chappelle's Show where his segments “Charlie Murphy’s True Hollywood Stories,” became a hit with fans and critics.
His death came a week before the one-year anniversary of Prince's death. In a strange coincidence, one of Murphy's most beloved Chappelle's Show skits was when he recounted a story about playing basketball with the "Purple Rain" singer in a segment of “True Hollywood Stories.”
The day before he died, Charlie Murphy sent out one last poignant tweet that seemed to signal he knew the end was near, writing, “One to sleep on: release the past to rest as deeply as possible.”
One to Sleep On: Release the past to rest as deeply as possible.
— Charlie Murphy (@charliemurphy) April 12, 2017
Tributes are pouring in from some of the late comedian's friends and colleagues.
Dave Chappelle, who was with rapper Talib Kweli at a John Mayer concert in Dayton, Ohio, took the stage to pay tribute to his late friend and colleague during the gig, a video of which Kweli posted on Instagram.
“My good friend Charlie Murphy passed away this morning and everybody in comedy is heartbroken,” Chappelle told the crowd.
Chris Rock, who directed Murphy in the cult favorite, CB4, posted on social media: "We just lost one of the funniest most real brothers of all time."
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"Prayers up for the Murphy family," actor Samuel L. Jackson tweeted. "Loved being around & working with Charlie!"
Donnell Rawlings, better known by the stage name Ashy Larry while starring with Murphy on Chappelle’s Show, posted an image of himself with Murphy on Instagram.
In 1997, Murphy married Tisha Taylor Murphy, who died of cervical cancer in 2009. The couple had two children.
He also has a third child from a previous relationship.
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