Schulz's 79-year-old widow was able to flee the property.
The final home of the creator of the iconic Peanuts comics is among the thousands destroyed by the raging wildfires in California's wine country.
Charles Schulz called Santa Rosa home from the late 1970's until his death in 2000. It was located in a hillside area affected by the Northern California blaze that has left more than 3,000 structures in ruins since Monday.
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Schulz's 78-year-old widow, Jean, was safely evacuated from the home Monday shortly before it went up in flames, their son told CNN.
The cartoonist was a beloved resident of Sonoma County, so much so that their airport bears his name. The Charles M. Schulz Museum and Research Center is also in Santa Rosa.
The museum is closed as firefighters continue to battle the blaze, which has killed more than 30 people and has become the deadliest wildfire in California history.
In a statement on its website, the museum said:
"At this time, the Schulz Museum is currently closed due to lack of power caused by the devastating fires in Santa Rosa. We do not know at this time when we will reopen and will be updating our social media and website with this information as we have it. All scheduled public programming, tours, and events through Saturday, October 14 are canceled at this time. On Sunday, October 15 we will send out an update regarding all programming for the week of Monday, October 16.
"While we are grateful our building was spared, our hearts go out to those members of our community that were less fortunate. Our thoughts are with everyone affected and we look forward to working with local organizations and businesses when we reopen to determine how best to give back to our community."
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Entire towns have been evacuated in Northern California as 25,000 people in Sonoma County alone have been forced to flee for their lives.
The fires have left an estimated 170,000 acres burned.
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